CEA Levels

Published on Jun 28 2010, in the categories: Ovarian cancer

The CEA refers to Carcinoembryonic Antigen. Elevated levels of CEA antigenicity are encountered in the cancer cases of benign and malignant stages. In the case of benign mediums, the amount of CEA antigenicity does not usually go beyond 10 ng/ ml, while the normal levels of CEA antigenicity remain around 2.5 and 5 mg/ ml. If these amounts rise higher than 2.5 mg/ ml, it is considered that this isn’t normal, and the association with a cancer diagnosis is accordingly done.

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The same amount of CEA however, can be found at cigarette smokers or patients with benign neoplasm, or at patients that suffer from inflammatory diseases such as colitis, pancreatitis, liver disease, Chron’s disease, or pulmonary infections. All in all, these raised levels of CEA are not usually met only in the case of cancer diseases, but they are rather a signal of malignancy at very high levels (> 20 mg/ ml). Also, the CEA levels need to be evaluated before a diagnosis concerning cancer is established, because they directly influenced the analysis results underwent by each patient.

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For example, each medical center needs to establish its own CEA levels. If the usual level for this medical center is 2.5 mg/ ml (the recommended level), then the upper values are considered abnormal and need further evaluation. If in some cases this limit is surpassed by a 5 mg/ml amount of CEA for only 4 % of the patients, obviously the patients suspected as having a benign disease will be lesser.

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Regarding to gynaecological malignances, the CEA levels is not considered to be a very important aspect to be evaluated. However, it is taken more into consideration only in some cancer types. The patients with ovarian cancer are those who usually have to undergo a CEA level analysis. The carcinoembryonic antigen placed in the plasma, and cyst fluid from patients having ovarian cystadenocarcinoma, are the elements to betray immunologic cancer.

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The higher CEA levels indicated malignancy. Also, the evaluation of CEA levels will help doctors to diagnose whether or not there is the possibility that an ovarian cancer to be recurrent or not. This can be established with the comparison of CEA level analysis prior to therapy, and after that.

The CEA levels are also very important and valuable for helping doctors establish a correct diagnosis of recurrence for patients who were treated with radiotherapy. Because of this type of therapy, the radiation fibrosis would harden the detection of tumours, if not totally impede it.

The CEA level analysis proves to be very helpful in disease marking concerning usual epithelial malignant tumors, whether these tumors refer to gynecologic malignancies or to patients who suffer from some benign diseases. In this way, the CEA levels would represent a very helpful way to determine and diagnose some tumors.

Since the discovery of CEA, patients suspected by cancer are initially tested for the CEA levels in the blood, in order to determine whether or not the antigen is present in the malignant lesion, before other tests will be done. Other information about CEA and the gynecologic cancer you can find on these two sites.

Ovarian Cysts and Sonograms

Published on Jun 27 2010, in the categories: Ovarian cancer, Tests

In the case of an ovarian cyst, this disease evolves as a fluid inside the normally solid ovary. Many ovarian cysts have been discovered until now, having different symptoms and forms, and unfortunately this illness is very commonly encountered at women, even if they are younger. The optimistic side of these discoveries is that many ovarian cysts aren’t necessarily a sign of cancer. Only the benign cysts necessitate special attention and treatments, because usually these cysts do not disappear without interventions. In some other rare cases, these benign cysts are cancerous. A symptom that can betray an ovarian cyst might be a discomfort sensed by the patient. In some other cases, this type of cyst can be depicted while a routine examination is done by a specialist, even if the person who requires this examination feels healthy.
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As the researchers found out, a good news is that many part of these ovarian cysts disappear without any surgical or treatment intervention. As most of the ovarian cysts are benign, the doctors don’t interpret them as very serious health problems, because there are already many ways to get rid of them.

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The most majority of ovarian cysts are named functional cysts. They are formed around a developing egg, from the fluid that surrounds the egg. This fluid forms periodically in the ovulation periods, around the developing eggs. In some occasions, this fluid forms larger than in normal cases, while this fluid determines the ovary to grow in dimension from within. If the fluid gathered in the ovary expands larger than a normal follicle, reaching to measure three quarters of an inch in diameter, then the suspicion of a follicular cyst is more and more probable. The ovary’s expansion resembles a balloon that was filled with water. The color of the surface that covers the ovary turns from white to gray in this case. These cysts usually don’t grow larger than 3 or 4 inches, and bug part of theses cysts disappear by themselves because they dissolve in the extra fluid in a month period.

In the time of ovulation, the covering of the ovary disappears and the egg gets out. After hours, this covering recovers, while the cells from the ovary regroup forming the corpus luteum. This corpus is responsible for the progesterone secretions, this hormone preparing the uterine lining cells that expect the fertilized egg. The corpus luteum forms every month, during the woman’s menstruation. Some cells that compose the corpus luteum can produce fluid inside this corpus, which will form cysts. Sometimes, in rare cases, these cysts can achieve dimensions of a few inches. Alike follicular cysts, corpus luteum cysts can disappear by themselves through disolvation during a month’s period. In many of these cases the corpus luteum cysts will disappear entirely, leaving no tracks.

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The vaginal sonograms are the most accurate examinations that can depict ovarian cysts. The sonogram procedures use a small instrument which can easily pass into the vagina. The small instrument that was introduced into the vagina will bounce some sound waves off the uterus, fallopian tubes and ovaries, in order to compose an image on a monitor. This image will be examined by the doctor and it will be interpreted in order to determine a diagnosis for each case. With the help of sonograms the cyst can be categorized more easily than through other methods. A site that will help you familiarize yourself with these type of cysts and sonograms is http://www.gynsecondopinion.com/.You can also find other information at http://www.i-ovariancancer.com/ovarian-cancer-article-2/.

Ovarian Cancer

Published on Jun 27 2010, in the categories: Ovarian cancer, Tests

The mostly used mode of diagnosis for the ovarian cancer is that of finding the prognostic factors. From these factors, the best known are stage and, in some advanced cases of disease, the volume of residual disease is also taken into consideration. At the other pole, there are factors such as the patient’s age, DNA ploidy, or histopathologic grade, which are less considered prognostic factors by specialists.
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The International Federation of Gynecology and Obstetrics (FIGO) created a well determined list of ways of staging the gynecological cancers. The FIGO stage is very accurate in ovarian cancer prognosis, compared to other methods. The staging of gynecological cancers takes into consideration both the surgical and pathological discoveries into account. This is why, a new term was brought to light, that of “surgicopathologic stage”.

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If a woman was diagnosed with FIGO stage I ovarian carcinoma, she must know that this prognosis is not very grave, as there are other prognosis. The FIGO stage I ovarian carcinoma can be discovered undergoing a special and complete gynecological procedure, which is done by a gynecological oncologist. At this stage I, the chances of recovery are exponentially bigger (90 %) than, as well as patients with stages IA and IB. The most dangerous stages of the stage I FIGO category are the grade 3 histogoly and IC substage. In these later stages, the survival rates are smaller than in the stage IA and IB cases (5 year survival for over 90 % of cases), the rate reaching smaller survival numbers. Even if the IC substage signifies malignant cells, it is possible that these cells are only exfoliated, while the most IB stages are more dangerous and they express separated primary tumors.

In the stage II of ovarian cancer are included the small and heterogeneous type of cancer, which represents 10 % of ovarian cancers. This stage refers to the extention of the ovarian cancer to other organs, specifically the pelvic, fallopian tubes, and pelvic peritoneum.

However, the ovarian cancer is mostly found in stage III, with a number of 50 % of the discovered cases. The characteristic of this type of cancer is its spreading towards the peritoneal regions, which are the pelvic and abdominal peritoneum. Also, the metastases to retroperitoneal lymph nodes are quite often encountered.

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Another stage for gynecological cancer is the stage IV, which includes parenchymal liver metastases or extra-abdominal metastases. The number of patients that were discovered in the IV stage reaches 13 %. The metastatic sites are found in these cases in the liver and lungs. Also, there is one-third of the patients that have ovarian cancer, who have pleural effusions, while ¾ of the women in this stage present malignant cells. In some of these cases, the metastases happen in the spleen as well, and they might need splenectomy. The brain metastases in the stage IV are less encountered and only 0.1 of the grave cases.

Nowadays, the grading of the gynecological or ovarian cancer is clinically necessary only to define the stage I of the disease’s evolution. This happens because at lower grade tumors, the chemotherapy may not be recommended. More information about the stages of ovarian cancer can be found at http://ovariancancer.jhmi.edu and http://www.i-ovariancancer.com/ovarian-cancer-stage/.

Endometriosis and ovarian cancer

Published on Jun 15 2010, in the categories: Ovarian cancer

PURPOSE: to describe the relationship between endometriosis and ovarian cancer. Search strategy: review of relevant clinical, epidemiological and molecular biology in the literature.Selection criteria: Studies published in English using the MEDLINE database. Data collection and analysis. Relevant studies were reviewed by three authors and what appeared to be of scientific significance, based on the methodology and statistical power were included and were considered the main results. Endometriosis and ovarian cancer share many predisposing factors.

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Both diseases show similar patterns concerning the local invasion and dissemination distal respond similarly to the signal induction and growth of estrogen, expressing resistance mechanism of apoptosis and are characterized by genomic instability. Endometrioid and clear cell type are the most common types of ovarian cancer associated with endometriosis. Tubal ligation in women with endometriosis, retrograde menstruation appears to prevent it but cit an also be produced in order to protect against these types of ovarian cancer.

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There is evidence to support that endometriosis (by definition a benign process), could simultaneously have the potential for malignant manifestations. More studies need to determine the risk factors that could lead to malignant manifestations of this disease and identify individual predispositions that may require close monitoring.

A comic opera, the definition of the President of the World Endometriosis Society. A late position on a habit that we recommend for years.
- Endometriosis and ovarian cancer: A review.
- Thoracic Endometriosis: an unusual case of hemothorax
- Transformation of residual tumor from endometriosis after hysterectomy: case series
- Origin and molecular pathogenesis of ovarian cancer: a review
- The presence of benign ovarian diseases related to the risk of developing epithelial ovarian cancer: role of ovarian surgery.
- The risk of cancer and the role of parity among women with endometriosis
- It can help diagnose the symptoms of endometriosis?
- Natural Hormones are Powerful Chemicals
- May 17, 2007 - Substantial Decline in Breast Cancer Rates
- L 'Endometriosis is linked to ovarian cancer molecular genetics - An order in Georgia to present the findings on dioxin
- 14 million women in Europe and 3 million in Italy suffer from Endometriosis
- More incidence of breast cancer in women, left-handed
- Tourism procreative in Ticino
- The low-dose oral contraceptives are associated with risk of myocardial infarction or stroke - Scientists identify a molecule Linked to Infertility
- Endometriosis and pain
- Innovative techniques for chronic pelvic pain symptoms deli
- A new medicine opens the hope of new treatments for endometriosis
- Dioxin and endometriosis
- Diabetes, autoimmune disorders and thyroid diseases and endometriosis
- Evidence on How endometriosis may impair fertility

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- Women with endometriosis have higher rates of certain diseases
- Identify fertile days with an algorithm
- A version with low-dose hormones for menopause approved by the FDA.
- Microwave destroy breast cancer
- Doll, died on the first cloned mammal in the world
- Osteoporosis by treatment with GnRH analogues
- Immune System and Endometriosis ...
- New drugs and endometriosis
- Breast cancer, ovary, etc., and Endometriosis
- Hormone therapy and breast cancer<
- Approved the House to protect the embryo
- Papillomavirus Infections
- From Dolly embryo

Herbs For Ovarian Cancer

Published on Jun 13 2010, in the categories: Ovarian cancer

Herbs for Ovarian Cancer:LAVANDA (Lavandula officinalis) Known to most of us mainly through its very fine and pungent aroma, the lavender is one of the plants with a long history in therapeutic use, are known and used since ancient times for its therapeutic action on the digestive system, nervous, circulatory, mitigation and for the effects of pain sensations. "Record as" the plant is confirmed by the latest research and filled with very few shares outstanding: the powerful antibiotic (including Staphylococcus aureus) and antifungal.

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Antidepressant effects comparable to those of powerful drugs currently used to treat these disorders are also important to be mentioned. It has also been recently demonstrated that anticancer effects (slowing down or stopping for a period of disease development) are due to some of the substances found in lavender. Lavender is among the few plants that can join the class painkillers, analgesics, which are natural and effective. Here are the main actions and general therapeutic indications of this plant.

Domestic: Plants: powerful anxiolytic, sedative good, easy analgesic, hypnotic environment, good antidepressant, antispasmodic powerful incentive, good peripheral blood circulation, good digestion, uterine stimulant, antifebril low intensity, good antiseptic, collar environment, cholagogue environment, good antimicrobial, anticancer, antioxidant, tonic general environment, good anti-inflammatory.

External: regenerating and revitalizing epithelial very good, strong anti-inflammatory, astringent, healing, healing wounds and burn speed, powerful antimicrobial (Staphylococcus aureus act strongly against him and Enterococcus faecium), strong antifungal (clear effects were found for infections such as Malassezia, Trichophyton rubrum, Trichisporon beigelii), anticancer, effectively stops hair loss and dandruff control, rheumatic good environmental ANTI-weak analgesic for moderate, good antioxidant.

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For indigestion, dyspepsia, flatulence, adjunct in biliary disorders it is recommended the powder. It has to be administered a teaspoon 4 times per day. For anorexia it is given lavender powder, ½ teaspoon every 20 minutes before each meal. Effects may be associated with increased powder thyme (Thymus vulgaris) leaf powder and marjoram (Majorana hortensis). For the substrate nervous intestinal disorder, diarrhea caused by stress - combined infusion, ½ cup four times a day. Additionally, for 10-15 minutes it is recommended to put something warm on the abdominal area (hot water bottle, heated salt).

Insomnia - Lavender has the effect of reducing both sleep time and sleep extension, while improving its quality. Volatile oil containing lavender (plant is currently at a rate of 1-3%) is - according to recent studies - as effective in treating sleep difficulties as well as some synthetic tranquilizers, but without their adverse effects. Combined infusion administered 2 tsp prepared from plant to cup water, 3 hours before bedtime. May be used "cushion" with lavender described external use.

Migraine and headache - combined infusion, 1 cup three times daily (used for several consecutive days according to the intensity of turbulence).

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Adjuvant in premenstrual syndrome - Lavender administration is indicated for the effects of elimination of harmful mental states that may occur during this period. At the beginning of menstruation can be observed a decrease in pain intensity characteristic of the period.Combined infusion administered - 3 cups per day.

Adjuvant in cancer disease (herbs for ovarian cancer)- was found in lavender existence of a substance called PHA, with certain anticancer effects, observed both in laboratory experiments and clinical trials. Clear results were obtained disease stabilization for a minimum period of six months in cases of cancer no longer responding to conventional treatments (chemotherapy,radiotherapy).

Cases have been pursued in these studies included prostate cancer, ovarian cancer, kidney, leukemia, sarcoma, liver cancer, pancreatic cancer, adenocarcinoma (Ripple and collaborators, 1998).Although further studies are still needed, lavender adjunct role in such cases is clear.Recommended powder (1 teaspoon four times daily) or soak in cold water (4 cups per day).Lavender administration has also reduced the effects of psychological tensions that arise in dealing with these diseases.

Ovarian Cancer Life Expectancy

Published on Jun 13 2010, in the categories: Ovarian cancer

Dr. Hamer found that all conflicts (or any disease) have a solution, and carrying any disease occurs in two phases. (The Second Biological Law). It also tried to explain the life expectancy in ovarian cancer.In the first stage of active conflict (i.e as long as it happens), the entire organism is oriented towards solving the conflict. While at the physical level there are specific cellular disorders, the psychic and autonomic nervous system is also confronted with unexpected situations. Switched to a stress phase (sympathicotonia), the mind becomes totally preoccupied with the conflict content. Sleep disturbances and lack of appetite are also important symptoms. Biologically speaking, it is vital to focus our attention on the conflict, the only way one can reach the conflict resolution.

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The active phase of conflict is called "cold phase". During stress, blood vessel constriction occurs, specific signs of activity are conflicting cold extremities (especially hands), trembling and cold sweat. Intensity of symptoms depends, naturally, on the intensity of the shock and on the impact of the conflict. If a person remains in this state for too long, there can be extremely serious consequences. Dr. Hamer has shown that the body cannot ever die of cancer itself. A person can die as a result of mechanical complications caused by tumors, such as blocking a vital organ such as colon or ball, but in any case the cancer cells in itself do not cause death.

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The German New Medicine differentiation between malignant or benign cancer has no value. Malignant deadline is an artificial construct (like marking tumor) that simply indicates a reproductive cell activity that has exceeded a certain arbitrary limit.

If a person dies during the initial phase of active conflict it is usually due to the loss of energy, excessive weight loss, lack of sleep and mental and emotional exhaustion, cases in which the life expectancy in the case of the ovarian cancer decreases. Most times it is the emotionally devastating impact of a diagnosis or prognosis of a negative, like "You have only six months to live!" That throws an impact on cancer patients and their loved ones who get into despair . Without hope they are deprived of their vital force, they consume energy unnecessarily and, eventually they die after an agonizing process because conventional cancer treatments do nothing more than to accelerate it.

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If the patient has not made any conventional cancer treatments (particularly chemotherapy or radiotherapy), NEG has a success rate of 95 to 98%. It is ironic that the statistics of the remarkable successes of Dr. Hamer were given even by the authorities. When Dr. Hamer was arrested in 1997 for providing medical advice without having his medical license for three people, police seized his medical records and analyzed them. A public prosecutor was forced to admit during the trial, that after five years, from 6500 to 6000 patients with terminal cancer were still alive whereas the conventional treatment figure is reversed.

Resolving conflict requires a beginning with initial signals generated by the second phase of the biological program. Emotions and our body should "fix" on to the healing program which is supported directly by the nervous system. During the healing phase, your appetite returns, but you are very tired (we even do not have the power to lift us out of bed). Rest and supply all necessary nutrients are essential during the healing process. The second phase is called phase of "hot" and, during this period, the blood vessels get larger, the extremities and the skin can wormer.

With conflict resolution, there is a change in organs, cell proliferation (commanded by the old brain - controlling tumor growth) and cellular destruction (commanded by the brain again - control tissue degradation) and immediately stop the repair process is triggered specifically.

Alternative Treatments For Ovarian Cancer

Published on Jun 13 2010, in the categories: Cases, Ovarian cancer

Diagnosed with cancer? If you or someone dear to you has been diagnosed with cancer, we offer you effective alternative treatments for ovarian cancer and herbal remedies with disinfection role in body detoxification . No matter what you read about herbal treatments to combat cancer, there is still hope by using products like: tincture of black walnut bark, zeolite, Zeo3, OxyE, detoxifying and pest package of 18 days. In fact, online store Ekilibrium.ro could end your search for ovarian cancer alternative treatments and remedies. Ekilibrium.ro sought and collected for you the most useful and effective cancer treatments and herbal remedies and has worked in these pages in a very easy way. And because we truly believe that everyone is entitled to have access to this material, free exhibits on this site are being accepted.

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These treatments and the herbal remedies: tincture of black walnut shells, zeolite, OxyE, Zormus, Zeo3, appliances pecum Zapper, sincrometru, ozone, MMS, zeolite, micro algae, stem cells, Biobran, OxyE are not known to all medical professionals. After 14 months of testing with a single natural remedy used by 65 patients diagnosed with stage 4 cancer, the state of 51 of them has improved using these products for healing cancer. You will learn the causes of this disease, and how you should not counter the causes and effects, including treatments and effective herbal remedies.

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Hundreds of people have walked this way before you and by using these treatments and herbal remedies they have defeated cancer. Cancer does not wait to celebrate a certain age. Cancer may be a very disturbing experience for your family or for your friends. Cancer can come when you least expect it. Change your attitude, do your tests on time, using these products for prevention and healing and keep in touch with your doctor!

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Ovarian Cancer Symtoms

Published on Jun 11 2010, in the categories: Ovarian cancer

Ovarian cancer prevention may be realized and the chance of developing it can be reduced by modifying the risk factors and behaviors and by getting a better understanding of its symptoms. Numerous studies have shown that the risk of developing ovarian cancer can be reduced by taking birth control pills (containing estrogen and progesterone) for a minimum of five years. One of these studies showed that even the most effective doses in the event of such an effect are lower doses of hormones, and the protective effect lasts for many years after women have stopped taking contraceptives. Such risks can be reduced even in the case of women who have a family history of pathological (cancer of the ovary or breast). Influencing through contraception does not seem possible but it is in in case there is a kind of gene mutations in the genes BRCA1 and 2.

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Another way to reduce cancer risks, which is considered as a more extreme one, and sometimes dramatic (if the woman is at reproductive age and wants to have children) is bilateral tubal ligation. Such a method is not recommended except in dangerous situations, when the risks of cancer are very high and only if it deems necessary and she no longer wants children. The procedure is not reversible, so such a decision must be made after having been well thought and after all the ovarian cancer symptoms have been carefully analyzed.

At least one pregnancy carried through can protect a woman's ovarian cancer and breastfeeding your baby seems to have similar protective effects. A relatively small percentage of women in the family have a first degree relative (mother, sister, daughter) or fence II (aunt or grandmother) diagnosed with breast or ovarian cancer. Experts have examined such families and concluded that there is a genetic family aggregation, due to mutations in BRCA genes, while mutations that will facilitate ovarian cancer. In such situations, how to quantify risk more accurately, genetic testing may be indicated to determine whether or not the patient has that mutation.

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Experts recommend generally that if women were to accept such a genetic mutation to their health security, surgery to remove the uterine tube, uterus and ovaries, while they are still do not appear healthy is recommended. This is the only method that can protect women from any background appeared ovarian cancer gene mutation that is inherited. Unfortunately, she could not have children, but the risk of developing cancer of the ovary is aggressive and is down over 95%. It should be noted that there is a small chance (but there) for patients to make a neoplasia of the ovary is removed ovaries even after the cancer started.

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Even if such a cancer is diagnosed in an early stage and is subsequently treated with surgery, there is the possibility of neoplastic contamination of other tissues and peritoneum there, even if it is not visible. That metastatic cancer cells then continue their development, and after surgery, at a certain time, the patient may be diagnosed with peritoneal cancer. Healthy diets and active lifestyles with no risk type of behaviors will not prevent cancer itself, but will stimulate the body to fight against any changes that might occur. Immune competent cells have the ability to monitor and destroy cells that divide and begin to modify their functional characteristics.

Mortality Ovarian Cancer

Published on Jun 11 2010, in the categories: Ovarian cancer

Ovarian cancer remains the leading cause of cancer death from gynecologic origin and the 4th cause of cancer death in women worldwide. In Europe, the mortality rate is between 3.6 and 9.3 to 100,000 women. If an early diagnosis is being established, the prognosis is very good. Unfortunately, 70% of cases the diagnosis is established in advanced stages when the survival rate is very law, only 10-30% of these patients surviving in one year.

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Symptoms of ovarian cancer are related to the presence of adnexal formations and are often vague and unspecific. The main purpose of the diagnostic evaluation of such formations is to determine if it is benign or malignant. It is estimated that in the U.S. 5-10% of women resorting recur to a surgical procedure for a suspected ovarian cancer, which is confirmed in 13-21% of cases.Since most of them are benign adnexal formations is very important to be able to determine preoperatively if a patient has an increased risk of ovarian cancer or not and to address an appropriate therapeutic attitude. This risk is assessed value and good positive correlation with clinical data's value of the tumor marker CA 125 (cancer antigen 125) and ultrasound examination.

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To improve the risk assessment for ovarian cancer and to decrease its mortality rate there have been created two new diagnostic tests. In September 2009, the Food and Drug Administration (FDA) has approved the test OVA1 ™ - the first blood test that, before exploratory surgery or biopsy, may help the doctor to determine whether a woman with an adnexal tumor is malignant or not , with a high sensitivity or not, even if radiological exporarile does indicate or not malignancy. The test is developed by Vermillion Inc. company. A molecular diagnostic company, in cooperation with the firm Quest Diagnostics - the world leader in cancer diagnosis. Ouest Diagnostics - long-term investor in research and development OVA1 ™ technology - holds the exclusive right to market clinical reference laboratories in the U.S. for the next three years.

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OVA1 ™ test is a qualitative in vitro diagnostic, which provides an index obtained by combining the results of five immunological tests using a patented algorithm, the numerical score achieved (between 0-10) indicating the risk of malignancy. This test indicated that 18 year old women and eve older ones who show an adnexal tumor and who were scheduled for surgery have not addressed the oncologist yet. The test uses the following biomarkers: transthyretin (TT or prealbumina) apolipoprotein A1 -A2- microglobulin ransferin CA 125 (cancer antigen 125)

The test should not be used without clinical and radiological assessment and should not be recommended as a screening test. The permitting process OVA1 ™ test, the FDA evaluated the results of a multicenter clinical trial, prospective, double blind, which included 27 different locations in terms of population. Vermillion Inc. company. Gynecologists Society of Oncology prize for a poster presented at the 38th annual meeting of the society on the issue of cancer in women in 2007 - entitled "Independent prospective validation of a panel of markers to differentiate benign from malignant pelvic formations. Results showed that the test correctly identified 84% of ovarian cancers, compared with only 33% identified by standard diagnostic methods.

In early February 2010, Abbott - a global leader in vitro diagnosis - the FDA approval under a new diagnostic test useful in monitoring patients with epithelial ovarian cancer - Architect HE4 (Human Epididymal Protein 4). If you receive approval, this important immunological test will automatically be the first test of this type. HE4 is a biomarker for detecting ovarian cancer, with a very low expression in normal ovarian tissue. Proper expression at the cellular level, high levels of HE were detected in the sera of four patients with ovarian cancer. HE 4 has a sensitivity of 70-80% at a specificity of 95-96% in diagnosing ovarian cancer.

Repeated determinations of HE4 and percentage growth estimates are useful in monitoring disease evolution and the emergence of the appellants in patients with epithelial ovarian cancer.This test should not be used as a screening test and no monitoring is recommended in patients with other types of ovarian tumors (mucinous, germ cells) - in which no growth of HE4. 4 Studies show that HE is more sensitive than CA 125, CA125 + HE4 combination - is more sensitive than either marker alone, and for stage I, HE4 alone is the most sensitive marker. Architect analyzer (Abbott) has the possibilities to carry out both determinations and to estimate the risk of ovarian cancer in women, depending on the status of pre-or post-menopause, by an algorithm called the Risk of Ovarian Malignancy ROME = Algorithm, set within a multicenter clinical trial, prospective, double blind, obtaining a predictive index: premenopausal - ROME 7.4% - low risk, 7.4% - high risk menopause - ROME 25.3% - low risk,25.3 - risk.

Ovarian Cancer Diagnostics

Published on Jun 08 2010, in the categories: Disease stages, Ovarian cancer

A new ovarian cancer diagnostic tool, which, according to studies may help determine the risk of malignancy or benign pelvic mass, is now available in Europe. This simple blood test can provide valuable information on the assessment of epithelial ovarian cancer, the most lethal gynecological cancer. It is an important immunological test, which runs on the system developed by Abbott ARCHITECT, HE4 was the first automated test available worldwide.

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Research has shown that this new ovarian cancer diagnostic device, used together with other tests, such as CA125 assessment can help measure the risk of epithelial ovarian cancer, both before menopause, and postmenopausal women presenting in the pelvic mass. According to the International Agency for Research on Cancer, five-year survival rate of patients with cancer is of 46 percent.

However, when the disease is diagnosed early, this rate increases to 94 percent. Ovarian cancer is the leading cause of death after contracting a gynecological cancer and the fifth cause of death from cancer in females. Ovarian cancer affects one in 72 women, this disease represents 31 percent of cancers of the female genitalia. After menopause, ovarian cancer risk increases considerably.

The ability of this test to help doctors to establish whether it is benign or malignant pelvic mass is an important step both for patients and for professionals", said Michael Warmuth, vice president of Abbott Diagnostics. "ARCHITECT HE4 test comes in to help doctors determine the most appropriate treatment for patients," he completes.

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In the new product development process, Abbott has signed a partnership agreement with Fujirebio Diagnostics Incorporated. The new tool is now available in several European countries, but in some countries in Asia and Latin America. Abbott recently sought the opinion of the U.S. Food and Drug Administration for marketing ARCHITECT HE4 test in the United States of America. Abbott Company provides medical services to global business activities which are dedicated to the discovery, development, manufacture and sale of medical products and pharmaceuticals. Company portfolio includes nutritional products, medical devices, diagnostic and hard. Abbott has over 72,000 employees and sells its products in over 130 countries.

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Meanwhile, the company's Diagnostic Division (Abbott Diagnostics) is a world leader in in-vitro diagnostics and offers a wide range of systems, medical instruments and tests innovative units for hospitals, medical laboratories, blood bank storage, clinics and offices medical. With more than 69,000 institutional customers in over 100 countries, the department offers consumers products that provide automation, convenience, cost efficiency and flexibility. Abbott Diagnostics portfolio contains many unique products a significant technological development, including the first diagnostic test to detect HIV.